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FLASH GENE
Symbol KCTD11 contributors: mct/npt - updated : 13-03-2014
HGNC name potassium channel tetramerisation domain containing 11
HGNC id 21302
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel    
Digestiveintestinesmall intestine   
 stomach   highly
Nervousnerve   highly
Reproductivefemale systemuteruscervix highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal BTB/POZ domain, required for the formation of a Cullin3 ubiquitin ligase complex and HDAC1 ubiquitination and degradation capability
  • several sites for N-myristoylation and phosphorylation
  • HOMOLOGY
    interspecies ortholog to murine Kctd11
    Homologene
    FAMILY potassium channel tetramerization domain (KCTD) family
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • voltage-gated potassium channel activity
  • seems to inhibit medulloblastoma growth by negatively regulating the Hedgehog pathway because it antagonizes the Gli-mediated transactivation of Hedgehog target genes
  • suppressor of Hedgehog signaling and suggests that its inactivation might lead to a deregulation of the tumor-promoting Hedgehog pathway in medulloblastoma
  • histone deacetylase and Cullin3-KCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through GLI acetylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • plays a crucial role in the ubiquitination of HDAC1 by acting, in complex with Cullin3, as an E3 ubiquitin ligase
  • KCTD6 is involved in the turnover of the muscle small ankyrin-1 isoform 5 and, in combination with KCTD11, in the ubiquitination and degradation of HDAC1
  • KCTD6(BTB) and KCTD11(BTB) bind CUL3 with high affinity forming stable complexes with 4:4 stoichiometries
  • cell & other
    REGULATION
    induced by retinoic acid
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in medulloblastoma
    tumoral     --low  
    reduced expression in medulloblastoma
    tumoral   LOH    
    frequently lost in human medulloblastoma (MB), in part by LOH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS