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FLASH GENE
Symbol KCNJ12 contributors: mct - updated : 27-10-2012
HGNC name potassium inwardly-rectifying channel, subfamily J, member 12
HGNC id 6258
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Reproductivefemale systemuterus   
Respiratorylung    
Urinarykidney    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two membrane-spanning domains
  • an amphipatic region pore,including the P domain with the K+ channel signature
  • an ATP-binding regulatory domain
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • potassium channel subfamily J
  • inward rectifier-type potassium channel family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • participating in establishing action potential waveform and excitability of neuronal and muscle tissues
  • KCNJ2 and KCNJ12 are primary determinants of endogenous K(+) conductance in aortic endothelial cells under resting conditions and KCNJ12 provides the dominant conductance in these cells
  • KCNJ2 and KCNJ12 have two distinct lipid requirements for activity: a specific requirement for INPP5J and a nonspecific requirement for anionic phospholipids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EDN1 inhibits human cardiac I(K1) current via a PKC-mediated phosphorylation of KCNJ12 channel subunits and additional regulatory effects on KCNJ4 channels
  • binding to INPP5J
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PPKCA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS