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FLASH GENE
Symbol SKA3 contributors: mct - updated : 14-01-2016
HGNC name spindle and kinetochore associated complex subunit 3
HGNC id 20262
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Reproductivemale systemtestis   
Urinarybladder    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal domains of SKA1 and SKA3 protrude at each end of the homodimer, bind microtubules when connected to the central core, and are essential
  • HOMOLOGY
    interspecies ortholog to murine F630043A04Rik
    Homologene
    FAMILY
  • SKA3 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • localizes to centrosomes, mitotic spindle, kinetochores during cell division
  • localizes to the spindle and to outer kinetochores throughout all phases of mitosis and is recruited to kinetochores by the core kinetochore-microtubule attachment factor HEC1
  • SKA3 protein accumulation at kinetochores in prometaphase is dependent on SGOL1 protein
  • basic FUNCTION
  • SKA3 functions to coordinate checkpoint signaling from the microtubule binding sites within a kinetochore by laterally linking the individual binding sites
  • is required for centrosome integrity and anaphase onset
  • important factor for metaphase to anaphase progression
  • SKA complex functionally complements the KMN network (CASC5, MIS12, NDC80), providing an additional layer of stability to kinetochore-microtubule attachment and possibly signalling completion of attachment to the spindle checkpoint
  • is a novel kinetochore protein, suggesting that SKA3 may have a direct role in mediating kinetochore-microtubule interactions
  • SKA1, SKA2 and SKA3 are required for stabilizing kinetochore-microtubule (KT-MT) interactions and silencing spindle checkpoint during mitosis
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the Ska complex, an essential mitotic component required for accurate cell division in human cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct interaction with a regulatory subunit of the PP2A
  • cell & other
    REGULATION
    Other phosphorylated during mitosis (Theis 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS