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FLASH GENE
Symbol SUPT5H contributors: mct - updated : 09-10-2013
HGNC name suppressor of Ty 5 homolog (S. cerevisiae)
HGNC id 11469
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Nervousbrain   highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • a very acidic 5'domain, and seven MAP kinase sites
  • two repeat-containing regions (CTR1 and CTR2CT) constituting the C-terminus of SUPT5H, play a redundant role in repressing RNAPII elongation, and C-terminus is critical for repressing RNAPII elongation ; modification of the CTR is crucial for recruitment of PAF1 to active genes
  • HOMOLOGY
    interspecies homolog to yeast Spt5 (histones group)
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • putative chromatin structure regulator
  • regulating mRNA processing and transcription elongation by RNA polymerase II
  • acting cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter
  • plays an important role in GATA1 gene expression and erythropoiesis through its transcriptional activation domain
  • SUPT4H1, SUPT5H can function independently in multiple transcription-coupled steps of class-switch recombination (CSR)
  • eukaryotic SUPT4H1-SUPT5H complex appears to couple chromatin modification states and RNA processing to transcription elongation
  • SUPT4H1-SUPT5H plays an important role in the recruitment of transcription elongation and RNA-processing factors to RNA pol II
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the DRB sensitivity-inducing factor complex (DSIF complex)
  • DSIF is composed of the two subunits, SUPT4H1 and SUPT5H
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDK7 thus acts through GTF2E1, GTF2E2 and SUPT5H to establish, and through CDK9 to relieve, barriers to elongation
  • MCM3AP interacts with the transcription stalling protein SUPT5H and facilitates RNA Pol-II recruitment to immunoglobulin variable regions
  • SUPT5H binding is mediated by an extended surface containing phosphothreonine recognition and hydrophobic interfaces that interact with AAs outside the SPT5H motif
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS