basic FUNCTION
| putative chromatin structure regulator |
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regulating mRNA processing and transcription elongation by RNA polymerase II |
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acting cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter |
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plays an important role in GATA1 gene expression and erythropoiesis through its transcriptional activation domain |
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SUPT4H1, SUPT5H can function independently in multiple transcription-coupled steps of class-switch recombination (CSR) |
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eukaryotic SUPT4H1-SUPT5H complex appears to couple chromatin modification states and RNA processing to transcription elongation |
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SUPT4H1-SUPT5H plays an important role in the recruitment of transcription elongation and RNA-processing factors to RNA pol II |