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FLASH GENE
Symbol SALL2 contributors: mct/npt - updated : 16-06-2009
HGNC name sal-like 2 (Drosophila)
HGNC id 10526
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinethyroid   highly
Nervousbrain   highly
 nerve   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C2HC zinc finger motif at the N terminus not present in SAL
  • four double zinc finger motifs (DZP)
  • a simple domain C2H2 associated to the third domain
  • glutamamine proline alanine and serine rich regions
  • HOMOLOGY
    interspecies homolog to Drosophila homeotic gene Sal-like 2
    homolog to Xenopus zinc finger protein XSAL1
    Homologene
    FAMILY
  • SAL family of C2H2 type zinc finger protein
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in the development and hematopoiesis through the WT1/SALL2 pathway
  • binding target of the polyomavirus large T antigen and acts as an inhibitor of viral DNA synthesis (Li 2004)
  • acting in part as a TP53-independent regulator of CDKN1A and BAX, can function in some cell types as a regulator of cell growth and survival (Li 2004)
  • activates target genes that modulate the growth and development of neurons (Pincheira 2008)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • novel NGFR-interacting protein that links NGF signaling to cell cycle progression and neurite outgrowth (Pincheira 2009)
  • cell & other
    REGULATION
    repressed by WT1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS