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FLASH GENE

Symbol

USF1

contributors: mct/npt/pgu - updated : 04-10-2016

HGNC name	upstream transcription factor 1
HGNC id	12593

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine large intestine       Endocrine thyroid       highly Reproductive female system breast mammary gland

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	DNA binding protein with helix-loop-helix (HLH)
	leucine zipper domain
	a core motif, CACGTG, termed E box

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Usf1

Homologene

FAMILY

basic helix-loop-helix leucine zipper family

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	transcription factor binded to a symmetrical DNA sequence that is found in a variety of viral and cellular promoters
	regulating several genes of lipid and glucose homeostasis
	recruits histone modification complexes and is critical for maintenance of a chromatin barrier
	serve as modulators in the induction of OSCAR and TNFSF11-mediated osteoclastogenesis
	activate the hepatic lipase promoter via E-box dependent and independent mechanisms
	USF1 and NFE2 together regulate the association of Pol II with the adult beta-globin gene promoter

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

USF1, PRMT1, and the histone acetyltransferases (HATs) KAT2B form a complex with both H4R3 histone methyltransferase and HAT activities

INTERACTION

DNA	binding to the AP-1/AP-4 site on the APP promoter

RNA

small molecule

protein	physical association between USF1 and GATA1
	interacts directly with the histone H4R3-specific methyltransferase PRMT1
	interaction with FADS3 (FADS3 expression is modulated by USF1)
	interact with and repress functional activities of key transcription factors involved in cellular differentiation, including USF1
	USF1 interacts with NFE2 in erythroid cells
	repression of USF1 transcriptional activity by HDAC9 could disrupt adipogenic differentiation
	PDX1 contributes to the transcriptional transactivation of ALX3 in pancreatic beta-cells by acting in co-ordination with USF1 and USF2 (pMID: 25040025)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

FCHL1

Susceptibility

to diabetes and atherosclerosis to male infertility with non-obstruction azoospermia (NOA)

Variant & Polymorphism SNP	intronic SNP increasing the risk of diabetes and atherosclerosis (in association with APOE mutations)
	variant rs2516838 of USF1 was associated with NOA susceptibility

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS