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FLASH GENE
Symbol TUB contributors: mct - updated : 30-05-2011
HGNC name tubby homolog (mouse)
HGNC id 12406
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Hearing/Equilibriumearinnercochlea highly Homo sapiens
Nervousbrain     Homo sapiens
Urinarykidney   highly
Visualeyeretina  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte Homo sapiens
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • its secretion is partially dependent on its PI(4,5)P(2)-binding activity with an essential secretory signal in the N-terminus
  • C-terminal PPBD domain is critical for tubby binding to apoptotic cells
  • HOMOLOGY
    interspecies homolog to murine (Tub) tubby gene (mild naturity onset obesity)
    Homologene
    FAMILY tubby protein family
    CATEGORY transcription factor , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • intracellular messenger of GPCR signaling in energy homeostasis
  • may be involved in the hypothalamic regulation of body weight
  • lacks phosphatidylserine-binding activity, but is capable of associating with PtdIns(4,5)P2 on the inner leaflet of the plasma membrane through its highly conserved C-terminal domain
  • Tubby and TULP1, but not other family members, enhanced the uptake of membrane vesicles by retinal pigment epithelium (RPE) cells in synergy
  • potential role for TUB in insulin signalling and fuel homeostasis in adipocytes
  • tubby and TULP1 are new type of MERTK ligands to facilitate phagocytosis
  • tubby and TULP1 have potentially a critical function as phagocytosis ligands in the maintenance of retinal homeostasis
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/hearing
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GPCR ligand and PLCB1
  • tubby and TULP1 are new MERTK ligands and facilitate phagocytosis in a MERTK-dependent manner (Tubby specifically binds to MERTK, whereas TULP1 interacts with all three RTKs in the TAM subfamily)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Deletion mutation of the 44 AAs at tubby C-terminal end (Tubby-deltaC44) causes adult-onset obesity, retinal and cochlear degeneration in Tubby mice with unknown pathological mechanisms