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FLASH GENE
Symbol DEDD2 contributors: npt/ - updated : 28-10-2005
HGNC name death effector domain containing 2
HGNC id 24450
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Urinarykidney   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • death effector domain
  • a nuclear localization signal (NLS)
  • mono polymer homomer , heteromer
    HOMOLOGY
    Homologene
    FAMILY
  • death effector protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • important mediator for death receptors and targeting caspases to the nucleus
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text CD95 induced apoptosis
    PATHWAY
    metabolism
    signaling
    a component
  • homodimerizing and heterodimerizing with DEDD and forming a complex with TFIIIC102
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TFIIIC102 translating
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS