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FLASH GENE
Symbol SLC36A2 contributors: SGE/npt - updated : 06-05-2010
HGNC name solute carrier family 36 (proton/amino acid symporter), member 2
HGNC id 18762
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Lymphoid/Immunespleen    
Nervousbrainlimbic systemhippocampus  
 brainhindbraincerebellum  
 spinal cordanterior horn   
Urinarykidneytubuleconvoluted tubuleproximal tubulehighly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Connectivebone   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 11 transmembrane domains
  • several N glycosylation site
  • three conserved histidine residues critical for proton binding
  • HOMOLOGY
    interspecies homolog to murine Slc36a2 (82.2pc)
    homolog to rattus Slc36a2 (81.5pc)
    intraspecies paralog to SLC36A1
    Homologene
    FAMILY
  • amino acid/auxin permease family
  • amino acid/polyamine transporter 2 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • having amino acid-polyamine transporter activity
  • contributing to neuronal transport and sequestration of amino acids such as glycine, alanine, and/or proline, whereby the transport direction is dependent on the sum of the driving forces such as substrate concentration, pH gradient, and membrane potential
  • acting as an electrogenic proton/amino acid symporter
  • in renal proximal tubule functions in the reabsorption of glycine, proline and hydroxyproline
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC36A2 also transports amino acid derivatives but has a narrower substrate selectivity and higher affinity (K(m) 0.1-0.7 mM) than SLC36A1
  • cell & other
    REGULATION
    inhibited by sarcosine
    ASSOCIATED DISORDERS
    corresponding disease(s) GCNU1
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate gene for 5q-myelodysplastic syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS