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FLASH GENE
Symbol TRAF3IP1 contributors: mct - updated : 30-08-2017
HGNC name TNF receptor-associated factor 3 interacting protein 1
HGNC id 17861
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Urinarykidney     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Urinaryepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eyes, lens, eye anterior segment, optic nerve, retina foveal and macular, RPE and choroid
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal calponin homology (CH) domain of IFT54 interacts with tubulins/MTs and has been proposed to transport tubulin during ciliogenesis
  • C-terminal coiled-coil domain, required for ubiquitination and proteasome-mediated degradation of TRAF3IP1 protein , that binds IFT20
    • whereas the C-terminal coiled-coil (CC) domain
    HOMOLOGY
    interspecies ortholog to C-Elegans DYF-11
    Homologene
    FAMILY
  • TRAF3IP1 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text localizes to cilia in the MDCK renal epithelial cells
    basic FUNCTION
  • required for sensory cilia formation
  • potential role in regulation of cytoskeleton dynamics in cells
  • TAF3IP1 function is highly conserved in ciliogenesis and is important for proper regulation of a number of essential developmental and cellular pathways
  • unexpected role of TRAF3IP1 as a negative regulator of microtubule stability via MAP4 (microtubule-associated protein 4)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • novel conserved component of the IFT complex
  • intraflagellar transport proteins IFT172, IFT80, IFT57, TRAF3IP1, CLUAP1, and IFT20 form a stable tubulin-binding IFT-B2 complex
  • subunit of the IFT-B complex required for ciliogenesis
  • component of the IFT-B complex and is also associated with cytoplasmic microtubules (MTs)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibitor of IL13 signaling
  • DISC1
  • complete loss of IFT54 or the CC domain destabilizes IFT20
    • cell & other
  • interaction with both actin filaments and microtubule suggesting that it may play an important role in regulation of cytoskeleton dynamics in cells
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Traf3ip1 mutant mouse cells are unable to form cilia