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FLASH GENE
Symbol DDX23 contributors: mct/npt - updated : 01-07-2010
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
HGNC id 17347
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryolfactory  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one helicase ATP-binding domain
  • one helicase C-terminal domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to yeast Prp28
    homolog to murine Ddx23 (98.7pc)
    homolog to rattus Ddx23 (98.7pc)
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX23/PRP28 subfamily
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having helicase, ATP binding, ATP dependent helicase activities
  • having function in spliceosome assembly (Mathew 2008)
  • may facilitate conformational changes in the spliceosome during pre-mRNA splicing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • spliceosome component required for splicing of nuclear pre-mRNA
  • component of the U5 snRNp complex
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein interaction with SRPK2 (role for SRPK2 in splicing and in spliceosome assembly) (Mathew 2008)
    cell & other
    REGULATION
    Other phosphorylation is required for its spliceosomal B complex association (Gustafson 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS