Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DYNLRB1 contributors: - updated : 21-02-2006
HGNC name dynein, light chain, roadblock-type 1
HGNC id 15468
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon lowly
 intestinesmall intestine  lowly
 liver   highly
Endocrinepancreas   highly
Lymphoid/Immunespleen   highly
Nervousbrain   highly
Reproductivemale systemprostate  lowly
 male systemtestis  lowly
Respiratorylung   lowly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta (moderately)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Dncl2a
intraspecies paralog to DNCL2B
Homologene
FAMILY
  • GAMAD family
  • MPP6 family
  • CATEGORY motor/contractile , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • involved in tumor progression
  • involved in microtubule-based movement
  • involved in assembly and motor function of dynein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component included in cytoplasmic dynein complex(dynein light chain)
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding with BMF and BCL2L11
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinomas (variant 1)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS