SUBCELLULAR LOCALIZATION
| plasma membrane
|
| intracellular
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
|
| intracellular,nucleus,chromatin/chromosome,centromere
|
text
| during mitosis, localized at the cell cortex, spindle poles, centromeres, central spindle, and midbody  |
basic FUNCTION
| RIC8A, RIC8B act together with GNAQ regulating neuronal transmitter release  |
|
GEF (guanine nucleotide exchange factor) for several alpha subunits of heterotrimeric GTP binding proteins (Galpha proteins)  |
|
acting as a guanine nucleotide exchange factor, catalyzes the release of GDP from various Galpha  |
|
its signaling leads to assembly of a cortical signaling complex that functions to orient the mitotic spindle  |
|
nonreceptor guanine nucleotide exchange factor  |
|
with RGS14 are recruited from the cytosol to the plasma membrane in the presence of coexpressed GNAI1 in cells, suggesting formation of a functional protein complex with GNAI1  |
|
RIC8A and and RIC8B are guanine nucleotide exchange factors that enhance different heterotrimeric guanine nucleotide-binding protein (G protein) signaling pathways  |
|
RIC8A and RIC8B are molecular chaperones required for the initial association of nascent Galpha subunits with cellular membranes |
|
RIC8A, RIC8B act as non-receptor GEF activators of G proteins in signal transduction contexts will be weighed against the evidence supporting the molecular chaperoning function of RIC8 in promoting G protein abundance  |
|
molecular chaperoning function of RIC8A is to participate in the folding of nascent G protein alpha subunits  |
|
RIC8A, RIC8B directly participates in the posttranslational folding of nascent Galpha subunits to promote G-protein biosynthesis  |
|
plays essential roles during the migration of cranial neural crest (NC) cells, possibly by regulating cell adhesion and spreading |