SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,chromatin/chromosome,centromere
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| text
| during mitosis, localized at the cell cortex, spindle poles, centromeres, central spindle, and midbody  |
| basic FUNCTION
| RIC8A, RIC8B act together with GNAQ regulating neuronal transmitter release |
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GEF (guanine nucleotide exchange factor) for several alpha subunits of heterotrimeric GTP binding proteins (Galpha proteins) |
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acting as a guanine nucleotide exchange factor, catalyzes the release of GDP from various Galpha |
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its signaling leads to assembly of a cortical signaling complex that functions to orient the mitotic spindle |
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nonreceptor guanine nucleotide exchange factor |
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with RGS14 are recruited from the cytosol to the plasma membrane in the presence of coexpressed GNAI1 in cells, suggesting formation of a functional protein complex with GNAI1 |
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RIC8A and and RIC8B are guanine nucleotide exchange factors that enhance different heterotrimeric guanine nucleotide-binding protein (G protein) signaling pathways |
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RIC8A and RIC8B are molecular chaperones required for the initial association of nascent Galpha subunits with cellular membranes |
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RIC8A, RIC8B act as non-receptor GEF activators of G proteins in signal transduction contexts will be weighed against the evidence supporting the molecular chaperoning function of RIC8 in promoting G protein abundance |
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molecular chaperoning function of RIC8A is to participate in the folding of nascent G protein alpha subunits |
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RIC8A, RIC8B directly participates in the posttranslational folding of nascent Galpha subunits to promote G-protein biosynthesis |
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plays essential roles during the migration of cranial neural crest (NC) cells, possibly by regulating cell adhesion and spreading |
