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FLASH GENE
Symbol TMEM259 contributors: mct - updated : 19-03-2020
HGNC name transmembrane protein 259
HGNC id 17039
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunelymph node   highly
 spleen    
Nervousbrainlimbic systemhippocampusdentate gyrus 
 plexus choroid    
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
not specificgranular cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal and 5 C-terminal transmembrane domains
  • potential sites for N-myristoylation and for phosphorylation
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • critical role of membralin in motor neuron survival, suggesting a novel mechanism for early-onset motor neuron disease
  • is an ERAD component, whith a reduction of mRNA and protein levels in Alzheimerdisease (AD) brain, suggesting a critical role for ERAD in Alzheimer pathogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian serous carcinomas, in effusion carcinoma, higher than in solid tumor, as compared to ovarian surface epithelium
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS