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FLASH GENE
Symbol ASB9 contributors: mct - updated : 15-04-2015
HGNC name ankyrin repeat and SOCS box-containing 9
HGNC id 17184
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six N terminal ankyrin (ANK) repeats
  • a conserved C-terminal SOCS box motif
  • HOMOLOGY
    interspecies homolog to murine Asb9
    Homologene
    FAMILY
  • ankyrin repeat and SOCS box-containing (ASB) family of proteins
  • SOCS box (ASB) family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • facilitates the polyubiquitination of CKB to mediate proteasomal degradation through the SOCS box domain
  • CELLULAR PROCESS protein, post translation, targeting
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • JAK kinases
  • activated cytokine receptors
  • elonguin B/C complex
  • CKB interacts with ASB9 in a specific, SOCS box-independent manner
  • ASB9 interacts with the creatine kinase system and negatively regulates cell growth
  • ankyrin repeat domains of ASB9 can associate with the substrate binding site of CMKT1A in a SOCS box-independent manner
  • specific substrate-recognition subunit of an elongin C-cullin-SOCS box E3 ubiquitin ligase complex
  • ASB9 binds to creatine kinase (CKB) and targets it for degradation
  • cell & other
    REGULATION
    induced by cytokines
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS