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FLASH GENE
Symbol EIF2B4 contributors: mct - updated : 15-05-2015
HGNC name eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
HGNC id 3260
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
Reproductivemale systemprostate  highly
Respiratorylung    
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion lymph highly
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Eif2b
homolog to rattus Eif2b
Homologene
FAMILY
  • EIF-2B alpha/beta/delta subunits family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP
  • CELLULAR PROCESS protein, translation/synthesis
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex of five different subunits, alpha, beta, gamma, delta and epsilon
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • EIF4G2 associates with EIF2B4 and EIF4A1 to stimulate Internal Ribosome Entry Sites (IRES)-dependent translation of cellular mRNAs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) VWM4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS