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FLASH GENE
Symbol HCAR3 contributors: mct/npt - updated : 11-09-2015
HGNC name hydroxycarboxylic acid receptor 3
HGNC id 16824
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
Reproductivemale systemprostate   
Respiratorylung    
Skin/Tegumentskin     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  predominantly
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil
Lymphoid/Immunelymphocyte
not specificadipocyte
Skin/Tegumentkeratinocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to GPR109A
Homologene
FAMILY
  • GPCR subfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating the anti-lipolytic and lipid-lowering effect of nicotinic acid
  • anti-lipolytic thiazoledinediones-induced gene in mature adipocytes (Jeninga 2009)
  • responsible for the antilipolytic and other effects of OH-octanoic acids in cells (Ahmed 2009)
  • may mediate a negative feedback loop that counterbalances prolipolytic stimuli in situations of strongly increased lipolysis and fatty acid oxidation to avoid an excessive lipolysis resulting in the waste of energy (Ahmed 2009)
  • HCAR2, HCAR3 play an essential role in the regulation of metabolic processes and immune reactions
  • possible specific role(s) of HCAR2, HCAR3 in human skin homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • niacin receptor
  • 3-OH-octanoic acid is an endogenous ligand of the orphan receptor GPR109B (Ahmed 2009)
  • cell & other
    REGULATION
    activated by hydroxy-carboxylic acid ligands which are intermediates of energy metabolism (Ahmed 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS