basic FUNCTION
| playing a role in apical membrane morphogenesis and tight junction regulation |
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plays potentially an important role in epithelial tight junction formation |
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potential expanded role for Crumbs proteins in polarized membrane targeting and cell division via unique interactions with importin proteins |
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seems to be involved in regulating the establishment and stability of tight junctions and in ciliogenesis |
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is crucial for epithelial morphogenesis and plays a role in linking the apical membrane to the underlying ezrin-containing cytoskeleton |
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is required for airway differentiation by controlling the localization of the transcriptional regulator YAP1 |
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is an actin microfilament regulator, playing a pivotal role in organizing actin filament bundles at the ES (ectoplasmic specialization) |
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CRB3 decreases cell proliferation, promotes apoptosis, and enhances the formation of tight and adherens junctions |
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regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells |
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role for CRB3 in regulating proliferation in mammalian cells that is associated with changes in the endocytic trafficking machinery |