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FLASH GENE
Symbol FATE1 contributors: mct - updated : 04-01-2012
HGNC name fetal and adult testis expressed 1
HGNC id 24683
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
Nervousbrain    
Reproductivemale systemtestis  predominantly Homo sapiens
Respiratorylung    
Urinarykidney    
cell lineage in tumor tissues (specifically hepatocarcinoma cells
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text testis specific
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 40-amino acid F-box motif
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may be a target of SF1 in testicular differentiation and/or germ cell development
  • involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through target proteins, such as cyclins, cyclin-dependent kinase inhibitors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other its expression is regulated by steroidogenic factor-1 (SF1) and Wilms tumor protein (WT1), two proteins involved in tumorigenesis, suggesting the role of FATE1 in tumor development
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS