protein
| associates with JNK1 through its C-terminal domain. JAMP association with JNK1 outcompetes JNK1 association with mitogen-activated protein kinase phosphatase 5, resulting in increased and prolonged JNK1 activity following stress |
|
RNF5 effect on JKAMP is seen prior to and after ER stress response, thereby highlighting a novel mechanism to limit ERAD and proteasome assembly at the ER, to the actual ER stress response |
|
RNF5 ubiquitinated JNK-associated membrane protein (JKAMP), a protein that recruits the proteasome to the ER membrane and that is negatively regulated by RNF5-mediated ubiquitination |
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RNF5 regulates the turnover of specific G protein-coupled receptors by ubiquitinating JKAMP and preventing proteasome recruitment |