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FLASH GENE
Symbol JKAMP contributors: mct - updated : 03-11-2015
HGNC name JNK1/MAPK8-associated membrane protein
HGNC id 20184
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 pharynx   highly
Endocrineadrenal gland   highly
Nervousbrain    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven-transmembrane domains
  • a zinc finger domain
  • and an N-glycosylation site
  • HOMOLOGY
    interspecies ortholog to murine Jamp
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • membrane-anchored regulator of the duration of JNK1 activity in response to diverse stress stimuli
  • links ER chaperones, channel proteins, ubiquitin ligases, and 26S proteasome subunits, thereby optimizing degradation of misfolded proteins
  • is an important component for coordinated clearance of misfolded proteins from the ER
  • 7-transmembrane protein located within the ER membrane that facilitates degradation of misfolded proteins through recruitment of proteasomes and ERAD regulatory components
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with JNK1 through its C-terminal domain. JAMP association with JNK1 outcompetes JNK1 association with mitogen-activated protein kinase phosphatase 5, resulting in increased and prolonged JNK1 activity following stress
  • RNF5 effect on JKAMP is seen prior to and after ER stress response, thereby highlighting a novel mechanism to limit ERAD and proteasome assembly at the ER, to the actual ER stress response
  • RNF5 ubiquitinated JNK-associated membrane protein (JKAMP), a protein that recruits the proteasome to the ER membrane and that is negatively regulated by RNF5-mediated ubiquitination
  • RNF5 regulates the turnover of specific G protein-coupled receptors by ubiquitinating JKAMP and preventing proteasome recruitment
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS