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FLASH GENE
Symbol RUFY1 contributors: mct/npt/pgu - updated : 13-03-2010
HGNC name RUN and FYVE domain containing 1
HGNC id 19760
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal RUN domain
  • a C terminal FYVE-finger domain
  • two coiled-coid domain in-between
  • HOMOLOGY
    interspecies ortholog to murine Rabpip4
    Homologene
    FAMILY
  • RUFY family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text present in early endosomes, because it is colocated with endogenous Early Endosome Antigen 1
    basic FUNCTION
  • effector of RAB4A, controling early endosomal traffic possibly by activating a backward transport step from recycling to sorting endosomes
  • controls SLC2A4 trafficking and plays a role in its endocytotic trafficking
  • via its interaction with RAB4A, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts
  • novel function for AP3B1 and RUFY1 in regulating lysosome positioning through an interorganellar pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text endosomal traffick
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ETK
  • RAB14 binds in a GTP-dependent manner to RUFY1, which had been originally identified as a RAB4A effector
  • cell & other
    REGULATION
    Other phosphorylated by ETK
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS