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FLASH GENE
Symbol SEC62 contributors: npt - updated : 24-04-2003
HGNC name SEC62 homolog (S. cerevisiae)
HGNC id 11846
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   moderately
Cardiovascularheart   highly
Digestiveliver   moderately
Endocrinepancreas   moderately
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila Trp1
homolog to yeast S.cerevisiae Sec62
Homologene
FAMILY
  • SEC62 family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • performing post-translational protein translocation into the ER when involved in Sec61-Sec62-Sec63 complex
  • performing the backward transport of ER proteins subject to the ubiquitin-proteasome-dependent degradation pathway when involved in Sec61-Sec62-Sec63 complex
  • involved in protein transport
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • forming a Sec61-Sec62-Sec63 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to ribosome-free SEC61 complex and SEC63
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS