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FLASH GENE
Symbol SEC61G contributors: SGE - updated : 13-04-2010
HGNC name Sec61 gamma subunit
HGNC id 18277
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   moderately
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , trimer
HOMOLOGY
interspecies homolog to yeast S.cerevisiae SSS1p
homolog to E.coli SecEp
homolog to murine Sec61g (100.00pc)
homolog to rattus Sec61g (100.00pc)
Homologene
FAMILY
  • SECE/SEC61-GAMMA family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text tail-anchored membrane protein
    basic FUNCTION
  • involved in protein translocation in the endoplasmic reticulum
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
  • heterotrimer of three membrane proteins- alpha, beta and gamma forming a transmembrane channel (Sec61 complex) where proteins are translocated across and integrated into the ER membrane
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS