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FLASH GENE

Symbol

RAD54L2

contributors: mlc/np - updated : 17-11-2007

HGNC name	RAD54-like 2 (S. cerevisiae)
HGNC id	29123

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear       highly Nervous nerve       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal region mediating interaction with AR

HOMOLOGY

interspecies

ortholog to murine Srisnf2l-pending

Homologene

FAMILY

CATEGORY

enzyme , DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	acting as an helicase
	active ATPase, and dsDNA (double-stranded DNA) and ssDNA (single-stranded DNA) enhancing its catalytic activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	nucleotide,
	ATP

protein

interacts with AR and binds to DNA and mononucleosomes

cell & other

REGULATION

Other

covalently modified by sumoylation, and mutation of six potential SUMO (small ubiquitin-related modifier) attachment sites abolished its ability to bind DNA, hydrolyse ATP and activate AR function

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS