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FLASH GENE
Symbol MICAL2 contributors: mct - updated : 19-09-2012
HGNC name microtubule associated monoxygenase, calponin and LIM domain containing 2
HGNC id 24693
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Digestiveliver   lowly
Nervousbrain   predominantly
Reproductivefemale systemovary  lowly
 male systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a LIM domain
  • HOMOLOGY
    interspecies homolog to Drosophila CG11685
    Homologene
    FAMILY MICAL family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • having a monooxygenase activity
  • involved in neuronal regeneration
  • conserved family of cytosolic multidomain proteins that has been shown to be associated with a variety of cellular processes, including axon guidance, cell movement, cell-cell junction formation, vesicle trafficking and cancer cell metastasis
  • possible role for MICAL genes in cardiovascular development
  • MICAL1, MICAL2, MICAL3, are required for normal actin organization, and all three MICALs regulate actin stress fibers
  • differential but complementary roles for MICAL1 and MICAL2 in actin microfilament regulation
  • atypical actin-regulatory protein, mediating SRF/MKL1-dependent gene transcription elicited by nerve growth factor and serum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism other
    signaling
    aromatic compound metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • induces redox-dependent depolymerization of nuclear actin, which decreases nuclear G-actin and increases MKL1 in the nucleus
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS