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FLASH GENE
Symbol TOX4 contributors: mct - updated : 13-10-2010
HGNC name TOX high mobility group box family member 4
HGNC id 20161
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Cardiovascularheart   highly
Digestiveliver   highly
Endocrinepancreas   highly
Nervousbrain   predominantly
Reproductivefemale systemovary  highly
 male systemtestis  highly
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • HMG box DNA-binding domain
  • C-terminus sufficient for the interaction with an N-terminal region of PPP1R10 that is distinct from its PP1-binding domain
  • HOMOLOGY
    Homologene
    FAMILY HMG-box protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcription regulation
  • potential role of the PTW/PP1 phosphatase complex in the regulation of chromatin structure during the transition from mitosis into interphase
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component stable multimeric complex composed of regulatory subunits PPP1R10, TOX4, and WDR82 , and PPP1CC catalytic subunit (denoted as the PTW/PP1 phosphatase complex)
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with PPP1R10 (transcriptional activity of TOX4 is markedly suppressed by its interaction with PPP1R10, in a PP1-independent manner)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS