motifs/domains
| a conserved C2 domain, an endosome anchoring domain, preferentially interacting with phosphoinositides, most notably with PtdIns3P (phosphatidylinositol 3-phosphate) and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate), in a Ca2+-independent manner |
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a TOM1 binding domain (TBD) that is involved in the interaction with TOM1, a protein that binds ubiquitinated proteins |
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a CUB domain, potentially involved in binding ubiquitin conjugating enzymes |
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a CUE (coupling of ubiquitin to endoplasmic reticulum degradation) domain in the C terminus, and this domain functions as an interaction motif for ubiquitinated proteins |
basic FUNCTION
| inhibiting IRAK1 activity |
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inhibits cell activation by microbial products |
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required for sorting of IL1RI at late endosomes |
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functions as an endosomal adaptor linking IL1RI, via TOM1, to the endosomal degradation machinery |
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modulates IRAK function in the TLR signalling pathway |
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negative regulator of Toll-like receptor signaling |
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spatial expression of TOLLIP at different stages of gestation may play an important role in the pathophysiology of preeclampsia (PE) |
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modulates intracellular trafficking and degradation of TGFB receptors |
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is a critical regulator of the Toll-like receptor-mediated signalling pathway |
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acts as a novel modulator of ischaemia-reperfusion (I/R) injury by promoting neuronal apoptosis and ischaemic inflammation, which are largely mediated by suppression of AKT1 signalling |
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TOLLIP-mediated inhibition of WNT signaling may contribute not only to embryonic development, but also to carcinogenesis |
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can potentially coordinate multiple cellular pathways of trafficking and signaling, possibly by exploiting its ability to interact with ubiquitin and the sumoylation machinery |
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is a key negative regulator of innate immunity by preventing excessive proinflammatory responses |
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TOLLIP protects against neointima formation by negatively regulating vascular smooth muscle cell proliferation, dedifferentiation, and migration in an AKT1-dependent manner |
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