Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZFAT contributors: mct - updated : 06-11-2015
HGNC name zinc finger and AT hook domain containing
HGNC id 19899
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node     Homo sapiens
 spleen   highly Homo sapiens
 thymus     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/ImmuneB cell Homo sapiens
Lymphoid/Immunelymphocyte
Lymphoid/ImmuneT cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text highly in placenta and in umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one AT hook
  • 18 C2H2 zinc-finger domains
  • eight uncommon bulged-out helix-containing zinc-fingers, and six of their structures (ZF4, ZF5, ZF6, ZF10, ZF11, and ZF13) were determined
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to rattus Zfat (88.8 pc)
    homolog to murine Zfat (88.8 pc)
    Homologene
    FAMILY
  • zinc finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in transcriptional regulation
  • critical regulator involved in apoptosis and cell survival for immune-related cells
  • is an essential transcriptional regulator for hematopoietic differentiation in blood islands
  • involved in apoptosis, development and primitive hematopoiesis
  • is a critical regulator in peripheral T cell homeostasis and its TCR-mediated response
  • plays crucial roles as a novel cell-intrinsic factor both in peripheral T cell homeostasis and in TCR-mediated cellular response
  • roles of ZFAT in haematopoietic and angiogenesis, and possible involvement of ZFAT in haematopoietic malignancies
  • critically participates in the development of double-positive (DP) thymocytes through regulating the activities of MAPK14 and JNK
  • transcriptional regulator, involved in autoimmune thyroid disease, apoptosis, and immune-related cell survival
  • regulates the transcription of target genes by binding directly to the transcription start site (TSS) proximal region, and ZFAT-target genes play important roles in T-cell homeostasis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • is required for peripheral T-cell homeostasis through IL7R expression by controlling the FOXO1 protein
  • ZFAT-regulated BRPF1 expression was likely important for T-cell survival
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in T- and B-cells in the lymphoid tissues
    constitutional       loss of function
    in peripheral T-cells results in a reduction in the number of T-cells with decreased expression of the IL7R that is critical for T-cell homeostasis
    Susceptibility to autoimmune thyroid disease (AITD)
    Variant & Polymorphism SNP exon 9b-SNP10 increases the risk of autoimmune thyroid disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Zfat-deficiency in mice leads to a remarkable reduction in the number of the peripheral T cells
  • Zfat(-/-) mice are embryonic-lethal, with impaired differentiation of hematopoietic progenitor cells in blood islands, where Zfat is exactly expressed