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FLASH GENE
Symbol TRIM45 contributors: mct - updated : 12-07-2017
HGNC name tripartite motif-containing 45
HGNC id 19018
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Digestiveliver     Homo sapiens
Endocrinepancreas     Homo sapiens
Lymphoid/Immunethymus     Homo sapiens
Nervousbrain   highly Homo sapiens
Reproductivemale systemprostate    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
Text brain, lung, skeletal muscle, heart and intestine in 80-day old embryo (Wang 2004)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING zinc finger, RING finger domain that is important for localization in the perinuclear region
  • two B-box domains (one type 1 and one type 2)
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a C-terminal (IG-FLMN) (filamin-type immunoglobulin) domain
  • HOMOLOGY
    interspecies homolog to rattus Trim45 (86.4 pc)
    homolog to murine Trim45 (86 pc)
    Homologene
    FAMILY
  • C-X TRIM family
  • RBCC (TRIM family)
  • RING-finger-containing E3 ligases family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    intracellular,nuclear envelope
    text
  • predominantly localized in the perinuclear region
  • basic FUNCTION
  • identifying specific cell compartments
  • may act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway (Wang 2004)
  • inhibiting transcriptional activities of ELK1 and JUN
  • acts likely as a repressor for the NFKB1 signal and regulates cell growth
  • regulates cell proliferation via inhibition in the NFKB1 signaling pathway
  • functions as a member of the negative feedback loop of the MAPK pathway
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • may affect cell proliferation via downregulation of NFKB1-mediated transcriptional activity
  • TRIM45 is a novel RACK1-interacting protein and downregulates MAPK signal transduction
  • is a novel tumor suppressor that stabilizes and activates TP53 in glioma
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS