protein
| MyoD |
|
CREB |
|
ribosomal protein L18a |
|
TBP and TFIIB |
|
Maf and Nrl |
|
DNA topoisomerase II, topo II |
|
CRE-BP1 |
|
tissue inhibitor of metalloproteinases-1, TIMP-1 and c-Ets-1 |
|
GHF-1 |
|
TFIIE-34, TFIIF-30, and TFIIF-74 |
|
B-ATF |
|
Ubc9 |
|
JAB1 |
|
ETS2 |
|
alpha chain of the nascent polypeptide-associated complex, alpha-NAC |
|
retinoblastoma protein, Rb |
|
Steroid receptor coactivator-1, SRC-1 |
|
Ergp55 and Fos |
|
Smad3 and Smad4 |
|
Nrf2 and Nrf1 |
|
retinoblastoma protein, Rb |
|
SPI-B |
|
vitamin D3 receptor, VDR |
|
NF-kappaB and AP-1 components c-Fos |
|
steroidogenic factor 1, SF-1 |
|
Stat3 |
|
Bcl3 |
|
C/EBP homologous protein 10, CHOP |
|
Silencing mediator of retinoic acid and thyroid hormone receptors, SMRT |
|
SUMO-1 |
|
ASC-2 |
|
BAF60a |
|
Cbfa and Runt |
|
TAF(II)250 |
|
TG-interacting factor, TGIF |
|
estrogen receptor alpha, ERalpha |
|
Pin1 |
|
homeodomain-containing protein Hex |
|
Cbfa1 |
|
hypoxia-inducible factor 1, HIF-1 |
|
coactivator of activating protein-1 (AP-1) and estrogen receptors, CAPER |
|
STAT4 |
|
DEAD-box RNA helicase RHII/Gu |
|
PIAS1 and PIASxbeta |
|
nuclear factor Y, NFY |
|
Protein kinase D, PKD |
|
Ski |
|
BRCA1 |
|
BCL-6 |
|
Receptor-interacting protein 140, RIP140 |
|
Human COP1, huCOP1 |
|
histone deacetylase 3, HDAC3 |
|
Jun B |
|
Cofactor of BRCA1, COBRA1 |
|
promyelocytic leukemia, PML |
|
DNA topoisomerase I, Topo I |
|
TCF4 |
|
histone deacetylase-related protein, HDRP |
|
COOH-terminal Src kinase, CSK |
|
interaction of GAK with adaptor protein 1 (JUN) regulates lysosomal enzyme sorting |
|
F-box protein Fbl10/JHDM1B |
|
calcineurin, CaN |
|
SIRT1 |
|
c-Fos and MAZ |
|
p21(Cip1) |
|
c-Myc |
|
RING domain AP-1 co-activator-1, RACO-1 |
|
Mbd3 |
|
STAT6 and JUN proteins were found to physically cooperate with each other and upregulated IL24 gene transcription |
|
STRAP |
|
metastasis-associated protein 1, MTA1 |
|
receptor for activated C-kinase 1, Rack1 |
|
FOSB and JUN can derepress transcription from the SERPINB2 promoter which may have general significance for SERPINB2-expressing cells |
|
AATF is a nucleolar stress sensor, which is required as a cofactor for JUN-mediated apoptosis |
|
PAX2 promotes proliferation of colon cancer cells through JUN |
|
IPO13 may contribute to the pathogenesis of pterygium via modulation of KRT17 and JUN |
|
AFF2 is an upstream regulator of FOS and JUN, and further link deregulation of the immediate early response genes to the pathology of intellectual disability (ID)- and FRAXE-associated ID in particular |
|
KRIT1 loss of function causes a ROS-dependent upregulation of JUN |
|
RBPMS physically and functionally interacts with JUN |
|
role of APPL1 as a positive regulator of DVL2-dependent transcriptional activity of JUN |
|
COPS6 is involved in positively regulating the stability of JUN |
|
overexpression of COPS6 correlates with the upregulation of JUN target gene expression in cancer |
|
JUN can suppress adipocyte differentiation through the down-regulation of KLF15 at the transcriptional level |
|
BATF/JUNB and BATF/JUN complexes play important roles in osteoarthritic cartilage destruction through regulating anabolic and catabolic gene expression in chondrocytes |
|
MEF2A and JUN confer antagonistic regulation of HSPB7 gene expression in skeletal muscle, with implications for autophagy and muscle atrophy |
|
JUN may cooperate with other partners to regulate FDX1 in Leydig cells |
|
HIPK1-phosphorylated PAGE4 (HIPK1-PAGE4) potentiates JUN, whereas CLK2-phosphorylated PAGE4 (CLK2-PAGE4) attenuates JUN activity |
|
hyperphosphorylation of PAGE4 by CLK2 attenuates this interaction with JUN |
| mouse embryonic stem (ES) cells lacking c-Jun are viable and have a normal in vitro differentiation capacity | |
primary Jun-/- fibroblasts have a severe proliferation defect and undergo premature senescence in vitro |
|
mouse primary JunAA (serines 63 and 73 mutated to alanines) fibroblasts have proliferation- and stress-induced apoptotic defects, accompanied by reduced AP-1 activity, and JunAA mice are viable and fertile, smaller than controls and resistant to epileptic seizures and neuronal apoptosis induced by the excitatory amino acid kainate |
|
mouse primary hepatocytes lacking c-Jun showed increased sensitivity to TNF-alpha-induced apoptosis |
|
embryos lacking c-Jun die at mid- to late-gestation and exhibit impaired hepatogenesis, altered fetal liver erythropoiesis and generalized oedema |
|
Absence of mouse neuronal Jun reduced the speed of axonal regeneration following crush, and prevented most cut axons from reconnecting to their target, significantly reducing functional recovery ( |