SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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text
| condensed chromosome kinetochore |
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mainly associated with the meiotic spindle microtubules and concentrated on spindle poles at metaphase I and metaphase II stages |
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localizes to spindle poles and kinetochores in mammalian cells, yet its kinetochore localization is exclusive to chromosomes that have congressed to the metaphase plate and is absent on those that have not yet congressed |
basic FUNCTION
| involved in the functional and dynamic regulation of mitotic spindles |
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being necessary for normal spindle formation during mitosis |
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regulating mitotic spindle localization of AURKA |
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microtubule and kinetochore protein that may contribute to the regulatory network that controls separase activity |
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DCLRE1B and SPAG5 function together to enforce the prophase checkpoint in response to spindle stress |
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microtubule and kinetochore protein required for the maintenance of sister chromatid cohesion and centrosome integrity in human mitosis |
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stabilizes microtubules at the outer kinetochore |
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KIF2C, SPAG5 and KIF2B form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity |
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mitotic spindle-associated protein required for the correct alignment of all chromosomes at the metaphase plate |