basic FUNCTION
| inhibiting the activity of NF-kappaB |
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a negative regulator of NF- |
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B via two sequential activities: de-ubiquitination of Lys63-based chains and synthesis of Lys48-based chains on the TNF receptor-interacting protein (RIP) |
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regulating matrix nuclear localization |
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attenuates epidermal growth factor (EGF)/extracellular-signal-regulated kinase2 (ERK2) nuclear signaling |
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atypical nuclear receptor coregulator, reducing RAR activity |
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A20-binding protein that is also known to attenuate NF-kappaB activation, and inhibits NFKB1 processing |
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important role in the regulation of immunity and tissue homeostasis |
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sequential action of SHQ1 and TNIP1 is required for functional assembly of H/ACA RNPs |
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cannot bind directly to the H/ACA domain of TERC, and requires the core trimer DKC1-NOP10-NHP2 to be efficiently incorporated into the pre-RNP |
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negative regulator of antiviral signaling |
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cooperates with TAX1BP1 and TNFAIP3 to restrict antiviral signaling |
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essential anti-inflammatory component of TLR-signaling pathways that controls CEBPB activity |