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FLASH GENE
Symbol TRIM47 contributors: mct - updated : 21-11-2023
HGNC name tripartite motif-containing 47
HGNC id 19020
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine    
Lymphoid/Immunethymus   predominantly
Reproductivefemale systemovary   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING zinc finger
  • a B-box domain
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • two LXXLL motifs of interaction
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Trim47 (88.4 pc)
    homolog to rattus Trim47 (90.4 pc)
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing a role in the process of dedifferentiation associated with astrocytoma tumorigenesis
  • acts as a tumor oncogene in non-small cell lung carcinoma (NSCLC)
  • functional role of the TRIM47-SMAD4-CCL15 axis in colorectal cancer (CRC) progression
  • having likely an activity-regulated E3 ligase that drives excitatory synapse formation in hippocampal neurons
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • functional role of the TRIM47-FOXO1 axis in the progression of gliomas
  • a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • mechanistically, TRIM47 interacted physically with SMAD4, increasing its ubiquitination and degradation
  • TRIM47 inhibited FOXO1 expression by ubiquitination and degradation of FOXO1, thereby promoting glioma growth and progression
  • TRIM47 promoted the aerobic glycolysis of pancreatic cancer cells, which was largely dependent on the direct binding to and ubiquitination of FBP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in astrocytoma
    tumoral       gain of function
    in pancreatic cancer cells (
    tumoral     --over  
    correlated with poor prognosis in patients with Non-small cell lung carcinoma (NSCLC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a poor prognostic factor in both breast cancer and prostate cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivepancreas
    targeting TRIM47/FBP1 axis might provide a novel strategy to suppress the development of pancreatic cancer
    cancerbrainglioma/neuroblstoma
    TRIM47-FOXO1 axis is a potential target for glioma treatment
    cancerlung 
    potential therapeutic target in Non-small cell lung carcinoma (NSCLC)
    ANIMAL & CELL MODELS