SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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text
| associated with the kinetochore |
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with NDC80, co-localize at kinetochores beginning at prophase and ZW10 joins them later at prometaphase |
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ZWINT localizes to the kinetochore in prophase, before ZW10 localization, and remains at the kinetochore until anaphase, after ZW10 has dissociated |
basic FUNCTION
| required for stable association of CENPF and dynamitin but not BUB1 with the kinetochore |
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new component of the mitotic checkpoint |
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essential for kinetochore binding by components of the spindle assembly checkpoint |
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role for the kinetochore protein ZWINT in presynaptic events that are regulated by RAB3A, RAB3B, RAB3C and SNAP25 |
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RAB3 specific binding protein that bound preferentially to RAB3C |
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kinetochore protein having a role in presynaptic events that are regulated by RAB3C and SNAP25 |
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is a structural protein, part of the inner kinetochore scaffold and recruits ZW10 to the kinetochore |