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FLASH GENE
Symbol ST18 contributors: mct/npt - updated : 30/10/2008
HGNC name suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
HGNC id 18695
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunespleen    
Nervousbrain    
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
Text in the developing CNS
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six fingers of the C2HC type (configuration Cys-X5-Cys-X12-His-X4-Cys)
  • a SMC domain
  • HOMOLOGY
    interspecies ortholog to murine St18
    homolog to rattus St18
    Homologene
    FAMILY
  • myelin transcription factor 1 (Myt1) gene family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • suppressor of tumorogenicity (may be the same than TSG8E)
  • having the potential to act as transcriptional regulator
  • may have a regulatory function in a specific phase during neuronal differentiation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    breast carcinoma
    tumoral     --low  
    a 160 bp region within the promoter is hypermethylated in about 80p100 of the breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS