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FLASH GENE
Symbol ZNF335 contributors: mct/npt - updated : 24-06-2016
HGNC name zinc finger protein 335
HGNC id 15807
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunespleen   highly
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six C2H2 zinc fingers
  • an LXXLL motif
  • a C-terminal leucine zipper region;
  • N-terminal 35-amino acid region enriched in acidic residues
  • putative protein kinase A
  • tyrosine kinase phosphorylation sites (Mahajan 2002)
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulator or coactivator of NRC function
  • enhancing the activity of nuclear hormone receptors as well as other transcription factors such as c-Fos and c-Jun (Garapaty 2009)
  • recruited to the receptor via association with NCOA6, which has been shown to bind directly to liganded RARA (Garapaty 2009)
  • transcriptional regulator that enhances the transcriptional activity of nuclear hormone receptors
  • directs neuronal morphogenesis during early developmental stages through modulating activity-dependent gene transcription
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • component of a complex with NCOA6
  • methyltransferase core proteins, ASH2L, RBBP5, and WDR5, form a physically separate complex with ZNF335 (Garapaty 2009)
  • INTERACTION
    DNA binds DNA and drives transcription via recognition of two distinct consensus motifs by separate ZF clusters
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • nuclear hormone receptor (NRC) transactivator
  • interacting with NCOA6 (does not directly interact with nuclear hormone receptors, it enhances activation by nuclear hormone receptors presumably through its interaction with NCOA6) (Garapathy 2009)
  • ZNF335 is a new interacting partner of CDK5R1
  • CDK5R1 interacts with ZNF335 and regulates its nucleocytoplasmic trafficking via the nuclear export pathway
  • binds to promoter regions via a consensus motif, and its target genes are enriched in categories related to protein metabolism, mitochondrial function, and transcriptional regulation and restoring the expression of one target, ANKLE2, partially rescues T cell maturation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH10
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mouse mutant, bloto, with a hypomorphic mutation in Zfp335; Zfp335(bloto/bloto) mice exhibit a na
  • ve T cell deficiency due to an intrinsic developmental defect that begins to manifest in the thymus and continues into the periphery