basic FUNCTION
| accelerating osteoblastic differentiation |
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required for binding of the methyltransferase complex to the K4-dimethylated H3 tail as well as for global H3 K4 trimethylation and HOX gene activation in human cells |
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acting as a module for recognition of a specific histone modification |
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involved in a mechanism for reading and writing an epigenetic mark for gene activation |
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playing a regulatory role in the developing growth plate |
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involved in binding and presenting histone H3K4 for further methylation as a component of MLL complexes |
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enhancing canonical Wnt signaling |
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may functions as a peptidyl arginine-recognition factor that facilitates the assembly of hCOMPASS and other chromatin modifying complexes |
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recruited to the TWIST1 promoter, a regulator of chondrocyte differentiation, suggesting overexpression of WDR5 in the perichondrium promotes chondrocyte differentiation by modulating the expression of TWIST1 and FGF18 |
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recruited to MAVS in a viral infection dependent manner |
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essential in assembling a virus-induced MAVS-associated complex and plays an important role in virus-triggered induction of type I IFNs |
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plays specific roles in maintaining an intact embryonic stem (ES) cell transcriptional network and, consequently, a self-renewal phenotype but is insufficient to block differentiation |
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critical for the maintenance of global and localized H3K4me3 and for transcriptional activation in ES cells |
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required for the initial reconfiguration phase of somatic cell reprogramming |
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implicated in control of activation of cell lineage genes during embryogenesis |
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critical substrate of CUL4B in regulating neuronal gene expression, suggesting epigenetic change as a common pathogenic mechanism for CUL4B-associated XLMR (X-linked mental retardation) |
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in conjunction with SRY, WDR5 plays an important role in sex determination |
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unique role for WDR5 in modulating the enzymatic activity of the KMT2C core complex |