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FLASH GENE
Symbol WDR18 contributors: mct - updated : 13-01-2014
HGNC name WD repeat domain 18
HGNC id 17956
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   moderately
Endocrineneuroendocrinepituitary  moderately
Lymphoid/Immunetonsils   moderately
Nervousbrain    
Reproductivefemale systemuteruscervix predominantly
 female systemovary  highly
Respiratorylung   moderately
cell lineage
cell lines
fluid/secretion highly in blood, moderately in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six WD repeats
  • HOMOLOGY
    interspecies homolog to dog WDR18 (89.8 pc)
    homolog to rattus Wdr18 (83.3 pc)
    homolog to murine Wdr18 (83.5 pc)
    Homologene
    FAMILY
  • WD repeat protein family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may be mediating protein-protein interactions
  • is a bona fide checkpoint protein and WDR18 works together with TOPBP1 to promote DNA damage checkpoint signaling
  • CELLULAR PROCESS cell life
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LAS1L interacts with PELP1, and WDR18, the mammalian homologues of the budding yeast Rix1 complex, along with NOL9 and SENP3, to form a novel nucleolar complex that cofractionates with the 60S preribosomal subunit
  • associates with the C-terminus of TOPBP1
  • facilitates ATR-dependent CHEK1 phosphorylation via interacting with both C-terminus of TOPBP1 and CHEK1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS