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FLASH GENE
Symbol WDR12 contributors: mct/npt - updated : 03/12/2008
HGNC name WD repeat domain 12
HGNC id 14098
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 pharynx   highly
Endocrinethyroid   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven WD repats (TRP-ASP domain)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be mediating protein-protein interactions
  • playing a crucial role for processing of the 32S precursor ribosomal RNA (rRNA) and cell proliferation
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of the Pes1-Bop1 complex (PeBoW complex, integrity of the PeBoW complex is required for ribosome biogenesis and cell proliferation in mammalian cells)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS