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FLASH GENE
Symbol VAT1 contributors: mct - updated : 08-06-2016
HGNC name vesicle amine transport protein 1 homolog (T californica)
HGNC id 16919
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
not specificepithelial cell
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria,outer
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,cytosolic,vesicle
intracellular,nucleus
text synaptic vesicle membrane
basic FUNCTION playing a role in in keratinocyte physiology, in particular in calcium-regulated processes, with no evident deregulation in malignancies of the breast and ovary
  • is a novel pathogenic factor in Benign prostatic hyperplasia (BPH) associated with cell proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • essential role for GPLD1 in the recruitment of VAT1 to membranes in human neutrophils
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    expression level was higher in both epithelial and stromal cells tissue in benign prostatic hyperplasia (BPH)than in normal prostate
    tumoral     --over  
    in glioblastomas and functionally involved in glioma cell migration, representing a new component involved in glioma invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS