Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UBE2N contributors: mct/ - updated : 02-07-2015
HGNC name ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
HGNC id 12492
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 pharynx   highly
Lymphoid/Immunetonsils   highly
Nervousbraindiencephalonamygdala  
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • ubiquitin-conjugating enzyme family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the covalent attachment of ubiquitin to other proteins
  • playing a role in the regulation of stress kinases and of the NF-B pathway
  • playing a critical and unexpected role in the initiation of homologous recombination at the level of DNA double-strand break processing
  • mediates lysine-63-specific protein ubiquitination involved in signal transduction by immune receptors
  • has a cell-intrinsic function in mediating hematopoiesis and is essential for the survival and accumulation of hematopoietic stem cells in the bone marrow
  • UBE2N and UBE2D1 had distinct effects on the conformational dynamics of STUB1, suggesting different roles of the STUB1-E2 interaction in the ubiquitination of substrates and interaction with chaperones
  • only known E2 ubiquitin (Ub)-conjugating enzyme that produces Lys-63-linked Ub chain with its cofactor E2 variant UBE2V1 or UBE2V2
  • UBE2N and STUB1 are novel factors in the regulation of cell surface availability of GHR
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ubiquitin-conjugating enzyme (E2) that heterodimerizes with UBE2V1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STK15
  • interacting with TRAF2
  • modifyed by ISG15 (suppresses its ubiquitin-conjugating activity)
  • ZNRF2, interact with UBE2N through its RING finger domain
  • TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of UBE2N and UBE2V1 to catalyse Lys 63-linked polyubiquitination, which activates the MAP3K7 kinase complex
  • OTUB1 binding to and inhibiting UBE2N, the cognate E2 enzyme for RNF168 and pharmacological targeting of the OTUB1-UBE2N interaction might enhance the DNA damage response
  • function of TRIM5 is dependent on its association with the E2 ubiquitin-conjugating enzyme complex UBE2N-UBE2V1 and subsequent activation of the MAP3K7 complex and downstream genes involved in innate immune responses
  • RNF8 regulates K48- and K63-linked poly-ubiquitylation via differential RING-dependent interactions with its E2s UBE2L6 and UBE2N, respectively
  • OTUB1 binding also occludes the RING E3 binding site on UBE2N, thus providing a further component of inhibition
  • UBE2N activity and its interaction with STUB1 precede endocytosis of GHR
  • UBE2N-CHUK signaling axis regulates the molecular program that maintains Treg cell function and prevents Treg cells from acquiring inflammatory phenotypes
  • RNF8 interacts with UBE2N in a manner that is similar to that of the RING-type E3 ubiquitin ligase TRAF6 and the U-box-type E3 ubiquitin ligase, STUB1
  • OTUB1 inhibits Lys-63-linked ubiquitination by binding to a ubiquitin-conjugating enzyme UBE2N
  • C1orf86 preferentially binds the ubiquitin product of RNF8-UBE2N, and this ubiquitin-binding activity and RNF8-UBE2N are both required for recruitment of C1orf86 to interstrand crosslinks
  • implicated in a bipartite role in priming and amplifying lys63-linked ubiquitin chains on histone molecules through coupling with the E3 RNF8 and RNF168
  • OTUB1 is a Lys48-specific deubiquitinating enzyme that forms a complex with E2 ubiquitin (Ub)-conjugating enzymes including UBE2N and UBE2D1
  • ATM-dependent phosphorylation of BCL10 promotes its interaction with and presentation of UBE2N to RNF8, and RNF8-mediated ubiquitination of BCL10 enhances binding of BCL10 and UBE2N to RNF168
  • UBE2N, UBE2L3 and UBE2D2/3 synergistically contribute to PRKN-mediated mitophagy
  • ZNRF1 is an essential E3 ligase implicated in diverse cellular pathways, and that binds UBE2N
  • cell & other
    REGULATION
    inhibited by OTUB1 that inhibits UBE2N and other E2 enzymes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS