basic FUNCTION
| alpha arrestin functioning as a natural antagonist of thioredoxin |
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having a unique role in epidermis regulating the conversion of postmitotic cells to differentiating ones |
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antitumor gene which forms a transcriptional repressor complex |
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involved in perinecrotic hypoxia |
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modulate overall gene transcription and thereby may further enhance beta-cell death and impair insulin secretion |
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regulator of the cellular redox state, but has also been suggested to act as a transcriptional repressor |
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required for normal glucose homeostasis in the liver |
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is a novel member of the MTOR upstream that acts as a negative regulator in response to stress signals |
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AMPK is an important regulator of TXNIP transcription via modulation of MLXIPL activity |
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has multiple functions and plays an important role in redox homeostasis, increasing the production of reactive oxygen species (ROS), and oxidative stress, resulting in cellular apoptosis |
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critical role for TXNIP in AGRP neurons in mediating diet-induced obesity through the regulation of energy expenditure and adipose tissue metabolism, independently of food intake |
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metabolic regulator, which modulates insulin sensitivity and likely plays a role in type 2 diabetes |
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major redox regulator and a Tumor Suppressor Gene (TSG) in various solid tumors and hematological malignancies |
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is a new regulator of the ECD-MDM2-TP53 loop |
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is a multifunctional protein involved in diverse cellular processes such as cell proliferation and apoptosis |