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FLASH GENE
Symbol TFAP2D contributors: mct - updated : 12-05-2016
HGNC name transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
HGNC id 15581
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • transcription factor AP-2 family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcription factor activity
  • functional role in recruiting histone methyltransferases (HMTs) to specific gene targets, such as HOXC8
  • is an important transcription factor, specifying gene expression patterns required for the development of the posterior midbrain
  • is a transcription factor important for modulating gene expression in embryogenesis
  • TFAP2D protein overexpression is linked to prostate cancer progression and genomic instability in ERG negative prostate cancers
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ASH2L positively mediates TFAP2D transactivation in a dose-dependent manner
  • FGFR3 is a transcriptional target of TFAP2D and ASH2L-containing histone methyltransferase complexes
  • occupies and activates the POU4F3 and BHLHB4 promoters
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer as compared to adjacent non-neoplastic glands
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Tfap2d-deficient mice failed to maintain the colliculus inferior, a derivative of the dorsal midbrain, as a consequence of increased apoptotic cell death