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FLASH GENE
Symbol SMARCE1 contributors: mct - updated : 10-05-2019
HGNC name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
HGNC id 11109
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinelarge intestine   
 mouth   highly
 pharynx   highly
Lymphoid/Immunespleen   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
Respiratoryalveolar macrophage
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text
  • placenta
  • constitutively expressed during development
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative nuclear localization signal
  • one HMG domain
  • a coiled-coil domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text nuclear matrix
    basic FUNCTION
  • required for transcriptional activation of genes normally repressed by chromatin
  • required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases
  • accessory component of the remodeling complex, and a critical regulator of androgen receptor function
  • critical modulator of the androgen receptor (AR) that is capable of altering AR activity, coactivator function, and AR-dependent proliferation
  • important role as regulator of estrogen receptor functions in breast cancer cells
  • having a role within the SWI/SNF complex that is required for maintaining the proper subunit composition of the complex and cell cycle progression through the transcriptional regulation of a subset of cell cycle-related genes
  • involved in the repression of neuron specific genes
  • TSHZ3 and SMARCE1 cooperate to modulate MYOD activity on the MYOG promoter to regulate skeletal muscle differentiation
  • role for SMARCE1 as a metastasis factor, a prognosis marker and a therapeutic target
  • is a key driver of invasive progression in early-stage tumors
  • SMARCB1, SMARCD1 and SMARCE1 might act as novel pro-senescence factors in both normal and tumor human skin cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of five multiprotein chromatin remodelling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I) and Brg1(II)
    INTERACTION
    DNA DNA binding
    RNA
    small molecule
    protein
  • binding to the SRC/p160 family of histone acetyltransferases (HATs) composed of NCOA1, NCOA2, and NCOA3
  • directly bind to the androgen receptor (AR) and is recruited to endogenous AR targets upon ligand activation
  • recruited to the AR DNA-binding domain/hinge region, which occurs concomitant with receptor activation
  • interacts with RCOR1, a protein that acts as a co-repressor of REST (RE1 silencing transcription factor), a transcription factor which represses neuronal genes in non-neuronal cells
  • interacted with SMARCA4 in oocytes and enhanced gene activation by thyroid hormone receptors cooperatively with SMARCA4
  • role of SMARCA4/SMARCE1-containing chromatin remodeling complexes in thyroid hormone receptors-regulated gene expression during postembryonic development
  • partner of TSHZ3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSSSCE1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in AR-dependent prostatic adenocarcinoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • putative marker of metastatic potential that could be leveraged for therapeutic intervention
  • predictive marker of endometrial carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    may be a target for ovarian cancer therapy
    cancerreproductiveprostate
    blockade of AR-SMARCE1 interaction is a novel means to target agonist-induced AR function in prostate cancer, and provide the first evidence that abrogation of SWI/SNF function can be developed as a point of therapeutic intervention in prostate cancer
    cancerreproductivebreast
    targeting SMARCE1 could represent a new way to effectively inhibit the action of ESR1 in breast cancer
    ANIMAL & CELL MODELS
    Smarce1 is overexpressed in the hippocampus but not in the kidney of tau deficient mice