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FLASH GENE
Symbol SLC39A3 contributors: mct/npt - updated : 24-03-2010
HGNC name solute carrier family 39 (zinc transporter), member 3
HGNC id 17128
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight-transmembrane domain proteins with a conserved 12-AAs signature sequence within the fourth transmembrane domain (Dufner-Beattie 2003)
  • HOMOLOGY
    Homologene
    FAMILY
  • ZIP transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • localized predominantly at the apical cell membrane (Desouki 2007)
  • basic FUNCTION
  • di,tri-valent inorganic cation transporter
  • maybe play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc (Dufner-Beattie 2003)
  • appear to be important for retention of the zinc in the cellular compartment (Desouki 2007)
  • seemingly associated with the re-uptake of zinc from prostatic fluid (Desouki 2007)
  • important zinc uptake transporter involved in the unique ability of prostate cells to accumulate high cellular zinc levels (Desouki 2007)
  • primarily plays a role in the reuptake and cellular retention of Zn in the mammary gland from the previously secreted milk pool, thus regulating cellular function (Kelleher 2009)
  • have unique cell-specific functions during adaptation to zinc deficiency (Kambe 2009)
  • is the important transporter required for the accumulation of zinc and its inhibition of proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate adenocarcinoma (Desouki 2007)
    tumoral     --low  
    the pathway of RREB1/SLC39A3/Zinc and its downregulation during oncogenesis exist to prevent the accumulation of cytotoxic levels of zinc during the development and progression of the malignant cells in pancreatic adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS