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FLASH GENE
Symbol SLCO1C1 contributors: mct - updated : 15-09-2021
HGNC name solute carrier organic anion transporter family, member 1C1
HGNC id 13819
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea  
Nervousbraindiencephalonhypothalamus  
Reproductivemale systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveLeydig cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one Kazal-like domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Slco1c1 (84.1pc)
    homolog to rattus Slco1c1 (84.8pc)
    Homologene
    FAMILY
  • organic anion transporter family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing an important role in the disposition of thyroid hormones in brain and testis
  • transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues
  • can transport fenamates (non steroidal antiinflammatory drugs) into brain barrier cells (Westholm 2009)
  • high affinity for thyroxine, tri-iodothyronine and reverse tri-iodothyronine
  • SLCO1C1 protein transports thyroid hormone into astrocytes from blood
  • unique gate-keeper function of SLC16A2 and SLCO1C1 in satellite cells (SCs) activation, underscoring the importance of a finely tuned TH signaling during myogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text transport ions
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may function as a pair with SLC16A2 to transport T4 from the blood into the cerebrospinal fluid and to efflux thyroid hormones to their inatives metabolites from the cerebral spinal fluid to blood (Roberts 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to hippocampal sclerosis of aging
    Variant & Polymorphism
  • polymorphism of the gene may be associated with fatigue and depression in patients suffering from hypothyroidism (Van der Deure 2008)
  • rs73069071 risk genotype was associated with hippocampal sclerosis (HS) pathology
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS