basic FUNCTION
| catalyzing heme formation |
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catalyzes the terminal step in the heme biosynthetic pathway, the insertion of ferrous iron into protoporphyrin IX |
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also participates in the reverse reaction of iron removal from heme |
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terminal enzyme in heme biosynthesis and catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX (heme) |
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catalyzes the insertion of ferrous iron into protoporphyrin IX to form heme |
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ferrochelatase (FECH), inserts iron into protoporphyrin IX (PPIX) to form heme |
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PGRMC1 may be likely a heme chaperone or sensor |
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FECH is an enzyme necessary for heme synthesis, which is essential for maintaining normal functions of endothelial nitric oxide synthase (eNOS) and soluble guanylyl cyclase (sGC) |