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FLASH GENE
Symbol RALY contributors: mct - updated : 16-09-2014
HGNC name RNA binding protein (autoantigenic, hnRNP-associated with lethal yellow)
HGNC id 15921
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY heterogeneous nuclear ribonucleoproteins family
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • involved in many processes of mRNA metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNA-dependent interactions of RALY with MATR3, PABPC1 and ELAVL1
  • protein-protein interaction of RALY with EIF4A3, FMRP, and HNRNPC
  • HNRNPH1, RALY, and TFG are proteins that specifically interact with the C-terminal domain of RBFOX1 and RBFOX2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to facial pigmented spots during aging
  • Variant & Polymorphism other
  • genetic variations in RALY/ASIP, contribute to the acquired amount of facial pigmented spots during aging, through pathways independent of the basal melanin production
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    may be a potential therapeutic target as well as a poor prognostic factor, in clear cell renal cell carcinoma
    ANIMAL & CELL MODELS