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FLASH GENE
Symbol POGZ contributors: mct - updated : 14-10-2015
HGNC name pogo transposable element with ZNF domain
HGNC id 18801
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly Homo sapiens
Hearing/Equilibriumearinnercochlea highly
Lymphoid/Immunelymph node   highly
Nervousbrain     Homo sapiensFetal
 brainhindbraincerebellum highly Homo sapiensAdult
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a transposase domain at the C-terminus
  • 9 C2H2-type zinc fingers
  • a zinc-finger-like motif, CBX5-binding domain, essential for normal mitotic progression and dissociation of CBX5 from mitotic chromosome arms, HP1-binding zinc-finger-like motif (amino acids 791–850) thought to be integral for the binding of POGZ to heterochromatin protein 1 (CBX5, or HP1) for proper mitotic progression
  • a CENPB-type DNA-binding domain
  • five functional domains
  • a centromere protein (CENP) B-like DNA-binding domain,
  • a DDE domain that might regulate gene expression
  • mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • having a nucleic acid binding function
  • required for the correct activation and dissociation of Aurora B kinase (AURKB) from chromosome arms during M phase
  • is involved in mitosis and the regulation of neuronal proliferation
  • essential protein that links CBX5 dissociation with Aurora B kinase activation during mitosis
  • have an important function in mitotic progression
  • heterochromatin protein 1 alpha-binding protein, that is likely a risk gene for neurodevelopmental disorders
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with the transcription factor SP1
  • interaction between the C terminus of PSIP1 and the DDE domain of POGZ, revealing an overlap in the binding of POGZ and HIV-1 integrase
  • bind to CBX5 through zinc-finger-like motif (interaction of POGZ with CBX5 may regulate Aurora B activation and a variety of downstream mitotic events)
  • POGZ is an essential protein that links CBX5 dissociation with AURKB activation during mitosis
  • PSIP1 interactions with transcriptional repressor CDCA7L and domesticated transposase POGZ, and the POGZ interaction is nearly identical to the interaction of PSIP1 with KMT2A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRD37
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    likely causative of ASD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS