basic FUNCTION
| playing an important role for axonogenesis through increasing the F-actin level |
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playing a role during neuronal differentiation |
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PLS3 gene may have an age- and gender-specific role in the clinical severity of SMA in children afflicted with this condition |
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is an actin-binding/bundling protein, with a role in Ca(2+) regulation that is essential for the function of PLS3 in motor axons |
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is a protein involved in actin bundle formation in the cytoskeleton |
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is a genuine SMA protective modifier |
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PLS3 is a modifier of SMA in motor-neurons (MN) |
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F-actin binding and bundling protein |
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in SMA, PLS3 and CORO1C but not TMOD3 play an important role in endocytosis by restoring F-actin-dependent processes |
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influences bone homeostasis through regulation of osteoclast activity |
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PLS3 serves an important role in EMT |
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plays a key role in cancer cell proliferation and invasion |
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Ca2+-dependent F-actin binding and bundling protein, associated with pathologies of the musculoskeletal system, nephrological disorders, malignancies of the solid and hematopoietic system, and numerous neuromuscular disorders |
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PLS3 is able to escape X chromosome inactivation in spinal MN |
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in contrast to the DXZ4 copy number, the regulation of PLS3 by CHD4/NuRD is not sex-specific |
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is regulated in a tissue-specific manner during embryonic development |